Susan E Bates Selected Research

Depsipeptides

5/2015	CCR 20th Anniversary Commentary: Expanding the Epigenetic Therapeutic Portfolio.
6/2011	Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma.
5/2010	Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
11/2009	Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma.
2/2007	The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems.
6/2006	Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma.
3/2006	Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).
6/2004	T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance.
3/2002	Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms.

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Susan E Bates Research Topics

Disease

101	Neoplasms (Cancer) 05/2022 - 01/2002
20	Breast Neoplasms (Breast Cancer) 01/2017 - 02/2002
15	T-Cell Lymphoma (Lymphoma, T Cell) 01/2021 - 06/2004
11	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 01/2021 - 02/2009
11	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 04/2016 - 06/2006
9	Renal Cell Carcinoma (Grawitz Tumor) 02/2015 - 07/2004
7	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 04/2004
7	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 12/2007
7	Carcinoma (Carcinomatosis) 04/2016 - 02/2002
5	Adenocarcinoma 01/2022 - 01/2020
5	Lung Neoplasms (Lung Cancer) 10/2013 - 02/2011
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 11/2007
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2018 - 09/2011
3	Melanoma (Melanoma, Malignant) 01/2022 - 02/2007
3	Neoplasm Metastasis (Metastasis) 01/2021 - 07/2005
3	Disease Progression 01/2021 - 01/2003
3	Squamous Cell Carcinoma of Head and Neck 10/2020 - 01/2019
3	Neutropenia 01/2019 - 05/2009
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2019 - 08/2010
3	Kidney Neoplasms (Kidney Cancer) 02/2013 - 01/2003
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/2012 - 05/2002
2	Testicular Neoplasms (Testicular Cancer) 01/2021 - 04/2004
2	Hemorrhage 01/2020 - 10/2019
2	Triple Negative Breast Neoplasms 01/2017 - 12/2011
2	Cardiotoxicity 06/2013 - 03/2002
2	Hematologic Neoplasms (Hematological Malignancy) 10/2012 - 12/2011
2	Gout 04/2011 - 01/2011
2	Infections 07/2010 - 02/2007
2	Neuroblastoma 05/2010 - 11/2002
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 02/2009 - 08/2006
2	Glioblastoma (Glioblastoma Multiforme) 02/2008 - 07/2005
2	Leukemia 12/2007 - 01/2003

Drug/Important Bio-Agent (IBA)

37	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
29	romidepsin (FK228)FDA Link 01/2021 - 03/2002
26	Histone Deacetylase InhibitorsIBA 01/2021 - 03/2002
24	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2002
19	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021 - 02/2002
14	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 05/2013 - 02/2002
13	Adenosine Triphosphate (ATP)IBA 01/2021 - 01/2002
9	DepsipeptidesIBA 05/2015 - 03/2002
9	Mitoxantrone (Novantrone)FDA LinkGeneric 08/2009 - 02/2002
7	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 07/2005
6	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2006
6	Cisplatin (Platino)FDA LinkGeneric 01/2019 - 04/2016
6	Tyrosine Kinase InhibitorsIBA 01/2019 - 03/2007
6	Topotecan (Hycamtin)FDA LinkGeneric 01/2018 - 11/2003
6	ErbB Receptors (EGF Receptor)IBA 01/2018 - 01/2002
5	belinostatIBA 01/2018 - 06/2009
5	Antineoplastic Agents (Antineoplastics)IBA 09/2014 - 04/2004
4	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 11/2002
4	Messenger RNA (mRNA)IBA 01/2019 - 09/2008
4	entinostat (MS 275)IBA 01/2018 - 11/2002
4	Etoposide (VP 16)FDA LinkGeneric 01/2018 - 07/2005
4	Vorinostat FDA Link 12/2014 - 06/2009
4	tariquidar (XR9576)IBA 01/2012 - 04/2007
4	multidrug resistance-associated protein 1IBA 09/2011 - 02/2002
4	EnzymesIBA 06/2007 - 03/2002
3	130-nm albumin-bound paclitaxelIBA 01/2022 - 01/2020
3	Gemcitabine FDA Link 01/2022 - 01/2020
3	Indicators and Reagents (Reagents)IBA 10/2020 - 02/2011
3	XenobioticsIBA 10/2013 - 04/2006
3	Histones (Histone)IBA 08/2013 - 03/2006
3	Sunitinib (Sutent)FDA Link 02/2013 - 02/2009
3	Imatinib Mesylate (Gleevec)FDA Link 01/2012 - 08/2006
3	Irinotecan (Camptosar)FDA LinkGeneric 08/2009 - 12/2007
3	Gefitinib (Iressa)FDA Link 02/2009 - 03/2007
2	folfirinoxIBA 01/2022 - 01/2021
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2021 - 10/2016
2	AntigensIBA 01/2021 - 09/2006
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 04/2011
2	Phosphotransferases (Kinase)IBA 01/2021 - 01/2012
2	AnticoagulantsIBA 01/2020 - 10/2019
2	ElectrolytesIBA 01/2019 - 07/2010
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2018 - 01/2012
2	MicroRNAs (MicroRNA)IBA 10/2013 - 09/2008
2	SmokeIBA 10/2013 - 08/2012
2	MagnesiumIBA 06/2013 - 07/2010
2	PotassiumIBA 06/2013 - 07/2010
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 02/2013 - 02/2009
2	FlavonoidsIBA 04/2011 - 06/2005
2	Vinblastine (Vinblastine Sulfate)FDA Link 11/2010 - 07/2004
2	Midazolam (Versed)FDA LinkGeneric 11/2010 - 10/2005
2	Cytochrome P-450 CYP3AIBA 11/2010 - 10/2005
2	ixabepilone (BMS 247550)FDA Link 09/2009 - 12/2007
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 02/2009 - 11/2007
2	Amino Acids FDA Link 02/2009 - 11/2002
2	alvocidib (flavopiridol)IBA 02/2009 - 01/2008
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 02/2007 - 10/2005
2	Photosensitizing Agents (Photosensitizers)IBA 12/2006 - 02/2005
2	Cytotoxins (Cytolysins)IBA 03/2006 - 04/2004
2	Cytostatic AgentsIBA 11/2003 - 05/2002
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 05/2022
1	Formaldehyde (Formol)FDA Link 01/2022

Therapy/Procedure

39	Therapeutics 01/2022 - 01/2003
14	Drug Therapy (Chemotherapy) 01/2021 - 01/2002
3	Neoadjuvant Therapy 01/2022 - 02/2019
3	Radiotherapy 02/2019 - 01/2019
2	Intravenous Infusions 01/2018 - 04/2016
2	Castration 01/2017 - 02/2011
2	Aftercare (After-Treatment) 02/2013 - 12/2007